Hybrid mathematical model of glioma progression
نویسندگان
چکیده
منابع مشابه
Hybrid mathematical model of glioma progression.
OBJECTIVES Gliomas are an important form of brain cancer, with high mortality rate. Mathematical models are often used to understand and predict their behaviour. However, using current modeling techniques one must choose between simulating individual cell behaviour and modeling tumours of clinically significant size. MATERIALS AND METHODS We propose a hybrid compartment-continuum-discrete mod...
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Experimental observations suggest that in the vicinity of the glioma-host interaction zone glioma cells secrete MMPs that dissolve the ECM composition and disturb the balance of the brain tissue [3]. In order to restore the natural balance, healthy brain cells try and produce more ECM components as well as secreting tissue inhibitor of the MMPs (TIMPs) [12]. In this paper we present a mathemati...
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Fossil Fuels are always considered as environmental pollutants. On the other hand, the political and economic situations highly affect the price of these fuels. Offshore wind and wave, as renewable energy sources, represent the better alternatives for electricity generation. Therefore, it is necessary that wind speeds effectively be estimated due to the absence of field measurements of the wind...
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Gliomas are highly aggressive and accompanied by numerous microglia/macrophages (MG/MP) in and about the tumor. Little is known about what MG/MP do in this setting, or whether modulating MG/MP activation might affect glioma progression. Here, we used a glioma-microglia in culture system to establish the effects the tumor and microglia have on each other. We assessed glioma progression in vivo a...
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ژورنال
عنوان ژورنال: Cell Proliferation
سال: 2009
ISSN: 0960-7722,1365-2184
DOI: 10.1111/j.1365-2184.2009.00631.x